New Tool For Assessing Heart Muscle Cells Helps Unlock Their Potential

CVRC’s very own, Wendy Crone, is the leader of a team of UW-Madison researchers who have developed an algorithm for image analysis that quantifies the organization and alignment of sarcomere structures within single cardiomyocytes, as well as a population of cells, with considerable accuracy. The team described its advance in a paper published May 19, 2020, in the Journal of Applied Physics.

“We want to produce mature cardiomyocytes with internal structures that are nicely organized and aligned, which allows them to work in a coordinated way with their neighboring cells to generate functional muscle behavior,” says Wendy Crone, a professor of engineering physics at the University of Wisconsin-Madison.

Crone says this new technique, called the scanning gradient Fourier transform (SGFT) method, gives researchers a valuable tool for evaluating cells and determining the most effective interventions for coaxing immature cardiomyocytes to become mature cells with highly organized internal structures.

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