Dr. Zachary Campbell, PhD
Visiting Associate Professor, Department of Anesthesiology
We welcome Zachary (Zach) Campbell, our newest CVRC member and Core Faulty. Zak joins us from the University of Texas at Dallas.
Area Of Research:
Pain is pervasive and devastating. Poorly treated chronic pain is the largest source of disability in America with an estimated economic cost of more than 500 billion dollars per year. Moreover, existing strategies to disrupt pain (e.g. opiates) have well known and highly undesirable effects on reward circuits in the CNS. Better strategies for preventing chronic pain are desperately needed. In the vast majority of cases, pain originates in the periphery in a specialized type of sensory neuron called a nociceptor. Long-lived changes in their excitability – which are intimately liked to chronic pain – require de novo protein synthesis. Multiple groups have shown that peripheral inhibition of protein synthesis diminishes pain associated behaviors in pre-clinical rodent models. This suggests that translation, likely in nerve fibers, is critical for nociceptive plasticity. But what are the mRNAs that need to be locally translated, what do their products do, and what governs the specificity of protein synthesis in nociceptors? To address these key questions, we make use of functional genomics, pharmacology, physiology, and genetic approaches.
Raising two wonderful children (Bob 9 and Tom 5), Labradors (Bella 3, Wander 3 months), running, gardening, and occasionally sleep.