Cynthia M. Carlsson, MD, MS

Position title: Associate Professor of Medicine (Geriatrics)

Email: cmc@medicine.wisc.edu

Phone: (608) 280-7000

 

Link to Department of Medicine

Research

Dr. Carlsson’s research focuses on the effects of vascular risk factors and their treatments on cognition and biomarkers for Alzheimer’s disease in persons at risk for dementia. Vascular risk factors in midlife, such as high cholesterol and elevated blood pressure, have been associated with an increased risk of developing Alzheimer’s disease decades later.  It is unknown, however, whether treating vascular risk factors will reduce the risk of dementia. Through partnering with research participants and colleagues in geriatrics, neuropsychology, cardiovascular medicine, neuroradiology, medical physics, and clinical chemistry, Dr. Carlsson is conducting clinical trials investigating:

  • The impact of vascular risk factors on risk of cognitive decline in middle-aged adults with parental history of Alzheimer’s disease
  • How vascular risk factors are related to biomarkers for Alzheimer’s disease found in the blood, cerebrospinal fluid (CSF), and on MRI scans measuring brain blood flow
  • The relationship between endothelial function, a measure of blood vessel function, and brain blood flow in persons at risk for Alzheimer’s disease
  • The effects of cholesterol-lowering medications known as ‘statins’ on CSF biomarkers, brain blood flow, and cognition in asymptomatic middle-aged adults with parental history of Alzheimer’s disease

Dr. Carlsson’s work has been supported by the National Institute on Aging (NIA), the American Federation for Aging Research (AFAR), the John A. Hartford Foundation, Atlantic Philanthropies, the Starr Foundation, the state of Wisconsin and the University of Wisconsin Department of Medicine and the General Clinical Research Center. Through their work, Dr. Carlsson and her colleagues hope to identify preclinical markers of Alzheimer’s disease risk as well as effective treatment strategies to delay the onset of dementia in persons at risk for the disease.