Alexey Glukhov, PhD

Link to Department of Medicine

Research

Dr. Glukhov’s research focuses on understanding the multicellular mechanisms involved in cardiac remodeling following heart failure and atrial fibrillation among multiple levels of cardiac signaling: from protein expression, phosphorylation, and sub-cellular localization, protein-protein interaction, to propagation and repolarization of an intact heart. His research combines several state-of-the-art techniques, including high-resolution fluorescent optical mapping and scanning ion conductance microscopy (SICM) equipped with “smart” patch-clamp. These are applied to investigate sub-cellular compartmentalization of ion channels and regulatory G-protein coupled receptors and their roles in atrial and ventricular arrhythmogenesis/dysfunction associated with different pathologies.