Alejandro Roldán-Alzate, PhD
Position title: Assistant Professor of Mechanical Engineering
Link to Cardiovascular Fluid Dynamics Laboratory
Our research focuses on combining magnetic resonance (MR) imaging in the body (in vivo) with 3D printed physical models (in vitro) based on actual patient specific scans. Separate physical models allow control of fluid properties not possible in vivo, as well as simulation of surgical interventions. The 3D models and in vitro 4D flow measurements allow validation of simulated using numeric models (in silico). The combination of these three techniques furthers development of patient specific methods for improving diagnostic and surgical outcomes.
Hemodynamics of Total Cavopulmonary Connection (TCPC)
Altered TCPC hemodynamics can cause long-term complications, and patient-specific anatomy hinders generalized solutions. 4D flow MRI, CFD, and physical model experiments with a perfusion pump to analyze the outcome of surgical procedures.
Patient Specific In-Vitro Models – Additive Manufacturing Approach
3D printed human anatomy can provide an important physical experiment for validating models. We use medical imaging to study the impact of various additive manufacturing (3D printing) methods to determine the more representative models.
Living Related Liver Transplant – Hemodynamics of the Living Donor
Living donor liver transplantation (LDLT) requires that the preoperational assessment be highly accurate. We are working to improve the assessment process of LDLT through the use of CFD, 4D Flow MRI, and printed physical model experiments.
4D Flow MRI: Patient Specific Intracranial Aneurysms
Using 4D Flow MRI, we study the flow dynamics through patient-specific intracranial aneurysms. Modeled from patient CT Angiography, we 3D print, scan, and visualize the flow patterns inside of the aneurysm and patient artery.