Zach received a B.S. in Chemistry from St. Norbert College and a Ph.D. in Molecular and Cellular Pharmacology from UW-Madison. He is currently a postdoctoral fellow in the laboratory of Dr. Timothy Kamp. His project is focused on identifying the protein constituents of caveolae, specialized microdomains of the plasmalemma, in cardiomyocytes using mass spectrometry-based proteomics. The importance of caveolae is underscored by the fact that mutations in caveolin-3, the principal structural protein component of caveolae in cardiomyocytes, have been associated with pathological conditions, including congenital long QT syndrome (LQTS), cardiomyopathy, and sudden infant death syndrome. A better understanding of the proteins present in caveolae will not only provide insights into the mechanisms of ion channel regulation and signal transduction, but may also aid the identification of novel susceptibility genes for pathological cardiovascular conditions from among the caveolar components.
Faculty Trainer: Timothy Kamp, MD/PhD, Cardiovascular Medicine