Research Statement: Madison received her Bachelors of Biomedical of Engineering from the College of Science and Engineering at the University of Minnesota. Her current graduate research at the University of Wisconsin in the Department of Biomedical engineering involves multi-scale computational modeling of mechano-energetic coupling in the right ventricle. Pulmonary hypertension causes pressure overload to the right ventricle, leading to right ventricular failure (RVF). RVF is a clinical syndrome characterized by reduced blood ejection from the right ventricle and elevated systemic venous pressure. A critical knowledge gap in this area of study is how changes at the organelle, cell, and tissue levels contribute to RVF at the organ and system levels. Specifically, our goal is to isolate and study fibrosis and metabolomics in diastolic and systolic dysfunction of the right ventricle using this multiscale in silico model of the cardiovascular system that is informed by in vitro and in vivo data.
Faculty Trainer: Naomi Chesler, PhD, Biomedical Engineering & Colleen Witzenburg, PhD, Biomedical Engineering